Novel oxylipins and other bioactive metabolites from marine algae

  • 215 Pages
  • 0.23 MB
  • English
Algae products., Marine algae., Biologicals., Marine metabol
Statementby Dale George Nagle.
The Physical Object
Pagination215 leaves, bound. :
ID Numbers
Open LibraryOL15395348M

Novel oxylipins and other bioactive metabolites from marine algae. Get PDF (8 MB) Abstract. Graduation date: I have participated in a drug discovery program designed to screen marine algae for\ud inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances,\ud and other agents of potential pharmaceutical.

Structure and biosynthesis of marine algal oxylipins. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism(3), DOI: /(94) S. Tahara, S. Kasai, M.

Inoue, J. Kawabata, J. Mizutani.

Description Novel oxylipins and other bioactive metabolites from marine algae PDF

Identification of mucondialdehyde as a novel stress by: Herein, we discuss recent findings on the biosynthesis of oxylipins in mammals and algae including an alternative pathway to prostaglandin E 2, a novel pathway to a precursor of leukotriene B 4, and the production of resolvins in algae.

We evaluate the pharmacological potential of the algal metabolites with implications in health and : Hans Jagusch, Tim U. Baumeister, Georg Pohnert, Georg Pohnert. Title: Novel Oxylipins and Other Bioactive Metabolites From Marine Algae Abstract approved: William H.

Gerwick I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility.

Marine algae are rich and heterogeneous sources of great chemical diversity, among which oxylipins are a well-recognized class of natural products. Algal oxylipins comprise an assortment of oxygenated, halogenated, and unsaturated functional groups and also several carbocycles, varying in ring size and position in lipid by: The overwhelming majority of marine oxylipins derive from LOX metabolism of PUFA of purified bioactive lipid compounds and novel oxylipins with those of other brown algae and diatoms.

Macrophytic marine algae, commonly known as seaweeds, are a rich source of unique natural products, many of which possess significant medicinal potential. Of particular interest are bioactive compounds produced through the regio-and stereo-selective oxidation of fatty acids or the halogenation of terpenoids.

Nine novel oxylipin metabolites together with several known ones were isolated from the brown alga Eisenia bicyclis. Five (1−5) of them are ecklonialactone derivatives containing a chlorine or an iodine atom, and two (6 and 7) are cymathere type oxylipins with a lactone ring or a chlorine atom.

The structures of these oxylipin metabolites were confirmed by NMR and mass spectroscopy and.

Download Novel oxylipins and other bioactive metabolites from marine algae PDF

NMR in seaweeds has been mainly employed for structural characterization of purified bioactive lipid compounds and novel oxylipins These same metabolites, along with other Marine algae are. Further, the purification of the bioactive metabolites from P.

chrysogenum is under process to get novel bioactive compounds. This study suggests that unravelling fungal endophytes from marine algae would provide prolific sources towards the bio discovery of new bioactive agents.

Details Novel oxylipins and other bioactive metabolites from marine algae EPUB

Antimicrobials by cyanobacteria. Various studies have indicated that both fresh and marine water cyanobacteria exhibit anticancer, antibacterial, antifungal, and pharmacological activities (Gul and Hamam,Mayer and Hamann, ).From secondary metabolites of cyanobacteria, various natural products have been derived that are produced because of mixed biosynthetic pathways.

Marine biota produce a variety of halogen containing organic compounds that have carbon atoms. Organisms that have the ability to form halogenated compounds have been found among various species of algae, bacteria, sponges, mollusks, coelenterates and several marine worms.

The oxygenated derivatives of fatty acids, known as oxylipins, are pivotal signaling molecules in animals and terrestrial plants. In animal systems, eicosanoids regulate cell differentiation, immune responses, and homeostasis.

In contrast, terrestrial plants use derivatives of C18 and C16 fatty acids as developmental or defense hormones. Marine algae have emerged early in the evolution of. Marine biotechnology is an upcoming area that involves about the study of marine microorganisms and animals including algae, sponges, and coral as a novel source of bioactive substances that can be used in the treatment of various human diseases like cancer, anemia, diarrhea, obesity, diabetes, atopic dermatitis, Crohn’s disease, etc.

A number of evidences have demonstrated that bioactive ingredients isolated from marine organisms can be other means to discover novel medicines, since enormous natural compounds from marine environment were specified to be anticancer, antibacterial, antifungal, antitumor, cytotoxic, cytostatic, anti-inflammatory, antiviral agents, etc.

Studies of the molecular mechanisms by which some of these marine oxylipins are formed have revealed that novel oxidative reactions are utilized. Understanding of these biosynthetic pathways in detail has allowed their utilization to produce research biochemicals of high value, such as 12 S -hydroperoxyeicosatetraenoic acid (12 S -HPETE).

Novel oxylipins and other bioactive metabolites from marine algae I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Nakienones A-C and nakitriol, a series of Cited by: 1.

of Marine algae compounds based on the number of previous studies. With an increasing number of bacteria and fungi metabolites the marine algae hold great promise for novel medicine and industrial application and also found to be rich source of structurally novel and biologically active metabolites.

References Athukorala, Y., Kil Nam Kim, and You. Numerous metabolites extracted from marine algae possess biological activities. These bioactive compounds have been widely acknowledged because of their potential health benefits [3, 29]. Commercial bioactive compounds of algal origin include natural pigments (NPs), polyunsaturated fatty acids (PUFAs), lipids, proteins and polysaccharides [15, 16].

Algae as production systems of bioactive compounds. Izabela Michalak. attention of scientists has been paid to novel methods, such as enzyme‐assisted extraction, microwave‐assisted extraction, pressurized liquid extraction, supercritical fluid extraction, and ultrasound‐assisted extraction, which enable the extraction of biologically.

Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments.

This is, and will be, a promising source for candidate. Metabolites with Potential Beneficial Activities from Marine Algae. Marine algae are the primary producers of oxygen in the aquatic environment and sit at the bottom of the marine food chain, serving all other organisms.

Marine algae can be divided into two main groups: macroalgae (seaweeds) and microalgae, both being prolific sources of. Novel 1,Netheno-2'-deoxyadenosine adducts from lipid peroxidation products.

Novel bioactive diterpenoid metabolites from tropical marine algae of the genus Halimeda (Chlorophyta). Tetrahedron (). of novel bioactive compounds including antibiotics, anti-cancer molecules, immunosuppressive agents, enzyme inhibitors, and pigments In this review, we focus on the production of novel antibiotics identified from marine algae, covering the literature to date.

Interesting natural products from microalgae and their anti-infective activities. Oxygenated fatty acids known as oxylipins play important roles in mammals, plants and fungi.

Here, the authors show that oxylipins, produced by the pathogenic bacteriumPseudomonas aeruginosa. Covering: to Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment.

Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment.

Because of their structural diversity and uniqueness. An important class of these oxylipins are the immunomodulatory leukotrienes (LTs). Besides mammals, marine algae produce bioactive oxylipins, including LTs. The novel acid-labile oxylipin, (5R,8S)-dihydroxy eicosatetraenoic acid, from the edible alga Gracilaria vermiculophylla rearranges via a 1,8-diol-forming mechanism to inflammatory LTB₄ e.

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Abstract: Diatoms are one of the main primary producers in aquatic ecosystems and occupy a vital link in the transfer of photosynthetically-fixed carbon through aquatic food webs.

Diatoms produce an array of biologically-active metabolites, many of which have been attributed as a form of chemical defence and may offer. Gary S. Caldwell, The Influence of Bioactive Oxylipins from Marine Diatoms on Invertebrate Reproduction and Development, Marine Drugs, /md, 7, 3, (), ().

Crossref. 15 Proteau P J. Oxylipins from temperate marine algae and a photoprotective sheath pigment from blue-green algae. Dissertation, Oregon State University ; 16 Todd J S, Proteau P J, Gerwick W H. The absolute configuration of ecklonialactones A, B, and E, novel oxylipins from brown algae of the genera Eckonia and Egregia.

This volume on medicinal foods from the sea narrates the bioactive principles of various marine floral (vertebrate and Invertebrate), faunal (Macro and Micro algal) and microbial sources.

Contributions from eminent scientists worldwide explain about the latest advance implications in the development and application of marine originated functional foods, as potential pharmaceuticals and.

• Several show pharmacological activities and are effective against cancer, AIDS, arthritis • Variety of molecules show unique structural features and exhibit various types of biological activities • Marine drugs are highly potent bioactive molecules In recent years a significant number of novel metabolites with potent pharmacological.Natural Products from Marine Algae: Methods and Protocols guides readers through protocols and techniques on algal biotechnology, metabolites, Solid-Liquid Extraction (SLE), Microwave Assisted Extraction (MAE), Liquid Chromatography, Gas Chromatography, Nuclear Magnetic Resonance Spectroscopy, Infra-red spectroscopy and Raman Spectroscopy.